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Audiol > Volume 9(1); 2013 > Article
Audiology 2013;9(1): 7-14.
Published online: June 30, 2013.
doi: http://dx.doi.org/10.21848/audiol.2013.9.1.7
나노입자에 기초한 의학치료와 연구
최철희1,2,3, 최성희1,2,3
1대구가톨릭대학교 언어청각치료학과
2생체모방감각제어연구소
3가톨릭 청각음성언어센터
Nanoparticle-Based Medical Therapy and Research
Chul-Hee Choi1,2,3, Seong Hee Choi1,2,3
1Department of Audiology and Speech-Language Pathology, College of Medical Sciences, Catholic University of Daegu, Kyung-Buk, Korea
2Research Institute of Biomimetic Sensory Control, Catholic University of Daegu, Kyung-Buk, Korea
3Catholic Hearing Voice Speech Center, Catholic University of Daegu, Kyung-Buk, Korea
Correspondence  Chul-Hee Choi ,Tel: 82-53-850-2541, Fax: 82-53-850-2540, Email: cchoi@cu.ac.kr
Received: May 3, 2013;  Accepted: June 10, 2013.  Published online: June 30, 2013.
ABSTRACT
Recently, a variety of nanoparticles have been considered as an attractive way that is effective and helpful in diagnosis and treatment of cancer and diseases through development in nanoscience and nanotechnology. Nanoparticles refer to tiny particles between 100 nm and 1 μm. The objective of this paper is to review the current applications, the research trend, and the possibility in future of the metallic nanoparticles in drug delivery, imaging, therapy, and combined imaging and therapy, as well as hearing research. The nanoparticles for effective drug delivery have been used to selectively target and kill the cancer cells or tumor cells and to transport molecules, nanoparticles, and cells into solid tumors in chemotherapy and radiation. The nanoparticles in hearing research have been used to prevent or treat the noise-, ototoxicity-, inflammatory-, viral-, and immune-mediated hearing loss and cell death processes using genetic and trophic factors enhancing repair processes of hair cell in the cochlea. The nanoparticles for effective imaging have been used to confirm a detailed view of targeting in live cells and their interactions with intracellular molecules and as contrast agents for CT, MRI, and x-ray imaging. The nanoparticles in therapy have been used in chemotherapy, immunotherapy, radiotherapy, thermotherapy, and photodynamic therapy by targeting the fast growing cells, blocking some critical elements of the cell division process, transporting various compositions, and increasing the dose and effectiveness of x-rays. Recently, the nanoparticles have been used to increase the effectiveness of individual modality image or therapy by combining noninvasive multimodality imaging and molecular therapy. This method can provide a new insight and intuition on the diagnosis and treatment of the various cancers and diseases including hearing loss.
Key Words: Nanoparticles, Drug delivery, Imaging, Therapy, Combining imaging with therapy, Hearing loss.
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