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Audiol > Volume 3(2); 2007 > Article
Audiology 2007;3(2): 131-134.
Published online: December 31, 2007.
doi: http://dx.doi.org/10.21848/audiol.2007.3.2.131
The Comparative Study of Aging and Auditory Evoked Potentials in the Mouse Model
Bin-Na Hong1, Ha-Na Hong2, Jae-Hyeok Lee3, Tong-Ho Kang3
1Department of Speech Pathology and Audiology, Nambu University, Gwangju, Korea
2Graduate Program in Audiology, Hallym University, Chuncheon, Korea
3Department of Oriental Pharmaceutical Development, Nambu University, Gwangju, Korea
Correspondence  Tong-Ho Kang ,Tel: +82-62-970-0163, Fax: +82-303-0300-0030, Email: panjae@gmail.com
Received: May 20, 2007;  Accepted: September 14, 2007.  Published online: December 31, 2007.
ABSTRACT
Objective:Presbycusis is a progressive hearing impairment associated with aging, characterized by hearing loss and a degeneration of cochlear structures. The mouse has been a useful model of presbycusis, as it displays an accelerated age-related peripheral hearing loss. The purpose of this study is compared with aging and auditory evoked potentials in the mouse. Method:Adult male ICR mice 7, 10, 17, 23 and 27 weeks were used in this study. In order to assess age-related hearing loss (AHL), we evaluated auditory brainstem response (ABR) and auditory middle latency response (AMLR) for the evaluation of sensorineural function in peripheral auditory nerve. Results:Hearing thresholds was significantly increased 17, 23 and 27 weeks after birthing comparing with 7 weeks in the mouse. Pa latency of AMLR was no difference for 6 weeks from 23 weeks group, Absolute latency of wave IV and interpeak latency of wave I-IV were significantly delayed for 6 weeks from 23 weeks group. The result suggests that significant changes of auditory evoked potentials from 17 weeks have taken place, age-related hearing loss (AHL) could be evaluated by the shift of hearing threshold and the increasing of ABR latency in the mouse.
Key Words: Aging·Mouse model·Auditory evoked potential.
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