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Audiol > Volume 8(1); 2012 > Article
Audiology 2012;8(1): 9-15.
Published online: June 30, 2012.
doi: http://dx.doi.org/10.21848/audiol.2012.8.1.9
쥐 와우의 영상 분석에 있어 Micro-CT의 가능성과 한계
최철희1,2,3
1대구가톨릭대학교 언어청각치료학과
2생체모방감각제어연구소
3가톨릭 청각음성언어센터
Possibility and Limitation of Micro-CT in Cochlear Imaging of Rat
Chul-Hee Choi1,2,3
1Department of Audiology and Speech-Language Pathology, College of Medical Sciences, Catholic University of Daegu, Kyung-Buk, Korea
2Research Institute of Biomimetic Sensory Control, Catholic University of Daegu, Kyung-Buk, Korea
3Catholic Hearing Voice Speech Center, Catholic University of Daegu, Kyung-Buk, Korea
Correspondence  Chul-Hee Choi ,Tel: (053) 850-2541, Fax: (053) 850-3383, Email: cchoi@cu.ac.kr
Received: April 30, 2012; Revised: June 13, 2012   Accepted: June 14, 2012.  Published online: June 30, 2012.
ABSTRACT
The objective of this study is to investigate the degree of visualization for the macro-, micro-, and nano-structures of the cochlea with x-ray micro-CT based on a cone-beam geometry for rats. This study will provide a basic criterion to compare the visual images obtained from other techniques. Before obtaining the visual images, the hearing thresholds were obtained with auditory brainstem responses (ABR). A x-ray micro CT based on a cone-beam geometry for a small animal was used for examining the macro-, micro-, and nano-structures of the cochlea in rats. X-ray micro CT provided a clear depiction of the basal, middle, and apical cochlear turns. X-ray micro CT allows visualizing the macro-structures of the cochlea. However, it did not well depict the micro- and nano-structures of the cochlea. The present study was the first attempt to visualize the macro-structures of the cochlea with x-ray micro CT based on a cone-beam geometry for rats. To visualize the micro- and nano-structures of the cochlea, optimal parameter values of x-ray micro CT should be found and many factors such as signal-to-noise ratio, resolution, image averaging, pixel, pixel number, pixel value, exposure time, and binning should be properly considered.
Key Words: X-ray micro CT, Macro-, micro-, and nano-structures, Cochlear mechanics, Visual image, Cone-beam geometry
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