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Audiol > Volume 4(1); 2008 > Article
Audiology 2008;4(1): 58-63.
Published online: June 30, 2008.
doi: http://dx.doi.org/10.21848/audiol.2008.4.1.58
ICR 마우스에서 Auditory Brainstem Response(ABR)의 Validation 연구
홍빛나1, 박태규1, 홍하나2, 강동호3
1남부대학교 언어치료청각학과
2한림대학교 일반대학원 협동과정 청각학전공
3남부대학교 한방제약개발학과
A Validation Study of Auditory Brainstem Response(ABR) in ICR Mouse
Bin Na Hong1, Tae Guy Park1, Ha Na Hong2, Tong Ho Kang3
1Department of Speech Pathology & Audiology, Nambu University, Gwangju, Korea
2Section of Audiology, Graduate School, Hallym University, Chuncheon, Korea
3Department of Oriental Pharmaceutical Development, Nambu University, Gwangju, Korea
Correspondence  Tong Ho Kang ,Tel: (062) 970-0163, Fax: (303) 0300-0030, Email: panjae@gmail.com
Received: May 2, 2008;  Accepted: June 14, 2008.  Published online: June 30, 2008.
ABSTRACT
The auditory brainstem response (ABR) has been used as the determination of hearing threshold and the assessment of integrity of a peripheral auditory nerve. In our study, ABR test was performed in ICR mouse according to stimulus type (click vs 4 kHz tone burst), ketamine dosage, test time after ketamine induction and body temperature respectively. Absolute peak and interpeak latencies were increased at 4 kHz tone burst stimulus comparing with click. Ketamine dosage and test times after ketamine induction were not influenced on absolute peak and interpeak latencies. Absolute peak and interpeak latencies in lower body temperature were increased comparing with normal body temperature. Thresholds according to stimulus type, ketamine dosage, test time and temperature were not significantly difference and thresholds were in normal ranges. Our validation study may enhance the reproducibility of ABR test in mouse model.
Key Words: Auditory brainstem response (ABR)·Mouse·Ketamine·Temperature.
중심단어: 청성뇌간유발반응· 마우스· Ketamine· 온도.
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