| 소음성 난청의 기전 |
| 양찬주, 정종우 |
| 울산대학교 의과대학 서울아산병원 이비인후과학교실 |
| Pathophysiology of Noise Induced Hearing Loss |
| Chan Joo Yang, Jong Woo Chung |
| Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea |
| Correspondence |
Jong Woo Chung ,Tel: +82-2-3010-3710, Fax: +82-2-489-2773, Email: gfinderjw@gmail.com
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Received: January 31, 2016; Accepted: March 10, 2016. Published online: March 31, 2016. |
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| ABSTRACT |
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Hearing loss due to the noise exposure has become a major cause of irreversible hearing disturbance and deafness. Hearing threshold
shift after noise exposure can be temporary or permanent. Noise-induced hearing loss can be caused by a one-time exposure to an intense
“impulse” sound or by continuous exposure to loud sounds over an extended period of time. The major mechanisms of noise-induced
hearing loss are physical damage in organ of Corti, decreased blood flow causing the hypoxia of the inner ear, oxidative stress of reactive
oxygen species (ROS), and neural degeneration in synaptic terminals of cochlear nerve fibers and spiral ganglion cells. Recent studies revealed
that the neural degeneration was also observed in temporary hearing threshold shift and cumulative damage in transient threshold
shift is likely to eventually lead to permanent hearing loss. This suggests that the repetitive transient noise-induced hearing loss can
cause age-related hearing loss. |
| Key Words:
Noise-induced hearing loss, Mechanism, Nerve degeneration. |
| 중심단어:
소음성 난청· 기전· 신경 변성. |
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